Ligand binding to the ACBD6 protein regulates the acyl-CoA transferase reactions in membranes
The binding determinants of the human acyl-CoA binding domain-containing protein (ACBD) 6 and its function in lipid renewal of membranes were investigated.ACBD6 binds acyl-CoAs of a chain length of 6 to 20 carbons.The stoichiometry of the association could not be fitted to a 1-to-1 model.Saturation of ACBD6 by C16:0-CoA required higher concentratio